Effect of mental fatigue on hand force production capacities.

Mental fatigue is common in society, but its effects on force production capacities remain unclear. This study aimed to investigate the impact of mental fatigue on maximal force production, rate of force development-scaling factor (RFD-SF), and force steadiness during handgrip contractions. Fourteen participants performed two randomized sessions, during which they either carried out a cognitively demanding task (i.e., a visual attention task) or a cognitively nondemanding task (i.e., documentary watching for 62 min). The mental fatigue was evaluated subjectively and objectively (performances and electroencephalography). Maximal voluntary contraction (MVC) force, RFD-SF, and force steadiness (i.e., force coefficient of variation at submaximal intensities; 25, 50, and 75% of MVC) were recorded before and after both tasks. The feeling of mental fatigue was much higher after completing the cognitively demanding task than after documentary watching (p < .001). During the cognitively demanding task, mental fatigue was evidenced by increased errors, missed trials, and decreased N100 amplitude over time. While no effect was reported on force steadiness, both tasks induced a decrease in MVC (p = .040), a force RFD-SF lower slope (p = .011), and a reduction in the coefficient of determination (p = .011). Nevertheless, these effects were not explicitly linked to mental fatigue since they appeared both after the mentally fatiguing task and after watching the documentary. The study highlights the importance of considering cognitive engagement and mental load when optimizing motor performance to mitigate adverse effects and improve force production capacities.

Effect of combined electrical stimulation and brief muscle lengthening on torque development.

This study aimed to evaluate torque production in response to the application of a brief muscle lengthening during neuromuscular electrical stimulation (NMES) applied over the posterior tibial nerve. Fifteen participants took part in three experimental sessions, where wide-pulse NMES delivered at 20 and 100 Hz (pulse duration of 1 ms applied during 15 s at an intensity evoking 5-10% of maximal voluntary contraction) was either applied alone (NMES condition) or in combination with a muscle lengthening at three distinct speeds (60, 180, or 300°/s; NMES + LEN condition). The torque-time integral (TTI) and the muscle activity following the stimulation trains [sustained electromyography (EMG)] were calculated for each condition. Results show that TTI and sustained EMG activity were higher for the NMES + LEN condition only when using 100-Hz stimulation, regardless of the lengthening speed (P = 0.029 and P = 0.007 for the two parameters, respectively). This indicates that superimposing a muscle lengthening to high-frequency NMES can enhance the total torque production, partly due to neural mechanisms, as evidenced by the higher sustained EMG activity. This finding has potential clinical relevance, especially when it comes to finding ways to enhance torque production to optimize the effectiveness of NMES training programs.NEW & NOTEWORTHY This study showed, for the first time, that the combined application of a brief muscle lengthening and wide-pulse neuromuscular electrical stimulation (NMES) delivered over the posterior tibial nerve can entail increased torque production as compared with the sole application of NMES. This observation, present only for high stimulation frequencies (100 Hz) and independently of the lengthening speed, is attributed to neural mechanisms, most probably related to increased afferents' solicitation, although muscular phenomena cannot be excluded.

Cadence Modulation during Eccentric Cycling Affects Perception of Effort But Not Neuromuscular Alterations.

INTRODUCTION: A recent study showed that cadence modulation during short eccentric cycling exercise affects oxygen consumption (V̇O 2 ), muscular activity (EMG), and perception of effort (PE). This study examined the effect of cadence on V̇O 2 , EMG, and PE during prolonged eccentric cycling and exercise-induced neuromuscular alterations. METHODS: Twenty-two participants completed three sessions 2-3 wk apart: 1) determination of the maximal concentric peak power output, familiarization with eccentric cycling at two cadences (30 and 60 rpm at 60% peak power output), and neuromuscular testing procedure; 2) and 3) 30 min of eccentric cycling exercise at a cadence of 30 or 60 rpm. PE, cardiorespiratory parameters, and vastus lateralis and rectus femoris EMG were collected during exercise. The knee extensors' maximal voluntary contraction torque, the torque evoked by double stimulations at 100 Hz (Dt100) and 10 Hz (Dt10), and the voluntary activation level were evaluated before and after exercise. RESULTS: V̇O 2 , EMG, and PE were greater at 30 than 60 rpm (all P < 0.05). Maximal voluntary contraction torque, evoked torque, and Dt10/Dt100 ratio decreased (all P < 0.01) without cadence effect (all P > 0.28). Voluntary activation level remained constant after both eccentric cycling exercises ( P = 0.87). CONCLUSIONS: When performed at the same power output, eccentric cycling exercise at 30 rpm elicited a greater PE, EMG, and cardiorespiratory demands than pedaling at 60 rpm. Exercise-induced fatigability was similar in both eccentric cycling conditions without neural impairments, suggesting that eccentric cycling seemed to alter more specifically muscular function, such as the excitation-contraction coupling process. In a rehabilitation context, eccentric cycling at 60 rpm seems more appropriate because it will induce lower PE for similar strength loss compared with 30 rpm.

Eccentric cycling involves greater mental demand and cortical activation of the frontoparietal network.

Eccentric, compared to concentric exercise, is proposed to involve different neuro-motor processing strategies and a higher level of mental demand. This study compared eccentric and concentric cycling at matched perceived effort and torque for the mental demand and related-cortical activation patterns. Nineteen men (30 ± 6 years) performed four different 5-min cycling conditions at 30 RPM on a semi-recumbent isokinetic cycle ergometer: (1) concentric at a moderate perceived effort (23 on the CR100® scale) without torque feedback; (2) concentric and (3) eccentric at the same average torque produced in the first condition; and (4) eccentric at the same moderate perceived effort than the first concentric condition. The conditions two to four were randomized. After each condition, mental demand was monitored using the NASA Task Load Index scale. Changes in oxy-(O2 Hb) and deoxy-(HHb) hemoglobin during exercise were measured over both prefrontal cortices and the right parietal lobe from a 15-probe layout using a continuous-wave NIRS system. Mental demand was significantly higher during eccentric compared to concentric cycling (+52%, p = 0.012) and when the exercise intensity was fixed by the torque rather than the perceived effort (+70%, p < 0.001). For both torque- or perceived effort-matched exercises, O2 Hb increased significantly (p < 0.001) in the left and right prefrontal cortices, and right parietal lobe, and HHb decreased in the left, and right, prefrontal cortices during eccentric compared to concentric cycling. This study supports that acute eccentric cycling, compared to concentric cycling, involves a higher mental demand, and frontoparietal network activation.

Acute smartphone use impairs vigilance and inhibition capacities.

Smartphones are now in very widespread use, and concerns have arisen about potential detrimental effects, even with acute use. These adverse consequences are often linked to the emergence of mental fatigue. While the cognitive implications of fatigue are well-documented, knowledge about the specific influence of acute smartphone use on cognitive performance remains scarce. The aim of this study was therefore to investigate the impact of acute smartphone use on cognitive performance. It included two experiments: one designed to assess the impact of smartphone use on vigilance, and the other focusing on evaluating inhibition capacities. In Experiment 1, two groups of 40 participants completed a Psychomotor Vigilance Task (PVT) before and after using a smartphone for 45 min (experimental group), or before and after watching a documentary (control group). In Experiment 2, two groups of 40 participants were subjected to a similar experimental design but had to perform a Go/NoGo task instead of a PVT. Mental fatigue and drowsiness were evaluated with visual analog scales before and after smartphone use and watching a documentary. Results suggested that both watching a documentary and using a smartphone for 45 min increased subjective mental fatigue and drowsiness. Watching the documentary did not impair cognitive performance. Reaction times on the PVT and number of errors on NoGo trials in the Go/NoGo task were higher among the participants in the smartphone condition. These results indicate reduced vigilance and impaired inhibition capacities only after smartphone use. We conclude that acute smartphone use induces mental fatigue and decreases cognitive performance. Further research is needed to understand the mechanisms underlying this decline in cognitive performance.

Effect of high-starch or high-fibre diets on the energy metabolism and physical performance of horses during an 8-week training period.

Large amounts of high-starch concentrates are traditionally fed to horses in training. However, this has been associated with digestive or muscle diseases and behavioural modifications. In parallel, it has been demonstrated that horses fed high-fibre, low-starch diets achieve the same performance over an exercise test as the ones fed high-starch diets. However, whether the same performance level can be maintained over a longer training cycle is still being determined. This study aimed to compare the evolution in physical performance and cardiorespiratory responses of two groups of French Trotters fed either a control high-starch (15.0 g dry matter hay/kg body mass/day + 6.6 g dry matter oats/kg body mass/day) or a high-fibre diet (75% of oats replaced by dehydrated alfalfa) over an 8-week training period. The horses that entered the trial were untrained for ≥4 months and previously fed hay only. Track training with speed monitoring included interval training sessions and 2400 m performance tests from week 1 to week 8 (W8). Before (week 0, W0) and after (week 9, W9) the training period, horses performed an incremental continuous exercise test during which cardiorespiratory parameters were measured. Both groups progressed to the same extent regarding physical performance measured during interval training sessions (acceleration: 0.16 m.s-2 at W0 and 0.40 m.s-2 at W8; p < 0.0001), the 2400 m performance test (average speed: 8.88 m.s-1 at W0 and 10.55 m.s-1 at W8; p < 0.0001), and the incremental continuous exercise test (speed during the fastest stage: 9.57 m.s-1 at W0 and 10.53 m.s-1 at W9; p = 0.030). Although oxygen consumption increased with training (p = 0.071), it was not influenced by the diet. On the contrary, carbon dioxide production increased in the high-starch group only (high-starch group: 84.0 vs. high-fibre group: 77.7 mL.kg-1.min-1 at W9; p = 0.031). The results illustrate that horses in both groups progressed similarly but did not use the same metabolic pathways during exercise. This hypothesis is supported by carbohydrate oxidation, which tended to increase in the high-starch group at W9 but decreased in the high-fibre group (p = 0.061). In conclusion, the substitution of high-starch by high-fibre diets enabled similar performance over an 8-week training period and altered energy metabolism in a way that could be beneficial during high-intensity exercise.

Does Smartphone Use Affect a Subsequent Swimming Training Session? Preliminary Results in Amateur Triathletes.

To date, the literature has failed to individuate a clear motivation for the performance decrement after a mental fatigue-inducing task. This study aimed to evaluate biomechanical and perceptual variables during a swimming training session in different mental fatigue states. Seven amateur triathletes watched a documentary, utilized a smartphone, or performed an AX-CPT for 45 min randomly on three different days. After, they performed a 15-min warm-up followed by 6 × 200 m at constant pre-set speed plus one 200 m at maximal effort. The mental fatigue status was assessed by the visual analog scale (VAS) and short-Stroop task results before, post-mental task, and post-swimming session. The biomechanical and motor coordination variables during swimming were assessed using five IMU sensors and video analysis. The heart rate and rate of perceived exertion were monitored during the task. No differences in biomechanical and perceptual variables were found between and within conditions. Higher mental fatigue was found only in the AX-CPT condition at post task by VAS. In this preliminary study, no changes in swimming biomechanics were highlighted by mental fatigue, but the warm-up performed may have counteracted its negative effects. Further studies are recommended.

A physiological comparison of the new-over 70 years of age-marathon record holder and his predecessor: A case report.

Purpose: This study assessed the body composition, cardiorespiratory fitness, fiber type and mitochondrial function, and training characteristics of a 71-year-old runner who broke the world record marathon of the men's 70-74 age category and held several other world records. The values were compared to those of the previous world-record holder. Methods: Body fat percentage was assessed using air-displacement plethysmography. V ˙ O 2 max , running economy, and maximum heart rate were measured during treadmill running. Muscle fiber typology and mitochondrial function were evaluated using a muscle biopsy. Results: Body fat percentage was 13.5%, V ˙ O 2 max was 46.6 ml kg-1 min-1, and maximum heartrate was 160 beats∙min-1. At the marathon pace (14.5 km h-1), his running economy was 170.5 ml kg-1 km-1. The gas exchange threshold and respiratory compensation point occurred at 75.7% and 93.9% of the V ˙ O 2 max , i.e., 13 km h-1 and 15 km h-1, respectively. The oxygen uptake at the marathon pace corresponded to 88.5% of V ˙ O 2 max . Vastus lateralis fiber content was 90.3% type I and 9.7% type II. Average distance was 139 km∙w-1 in the year prior to the record. Conclusion: The 71-year-old world-record holder marathon showed a relatively similar V ˙ O 2 max , lower percentage of V ˙ O 2 max at marathon pace, but a substantially better running economy than his predecessor. The better running economy may result from an almost double weekly training volume compared to the predecessor and a high type I fiber content. He trained every day in the last ∼1.5 years and achieved international performance in his age group category with a small (<5% per decade) age-related decline in marathon performance.

Effect of Cadence on Physiological and Perceptual Responses during Eccentric Cycling at Different Power Outputs.

INTRODUCTION: The effect of cadence in eccentric (ECC) cycling on physiological and perceptual responses is, to date, poorly understood. This study aimed to evaluate the effect of cadence during ECC cycling on muscular activation (EMG), oxygen consumption (V̇O 2 ), and perceived effort (PE) for two different levels of power output. METHODS: Seventeen participants completed four sessions 1 wk apart: 1) determination of the maximal concentric peak power output (PPO) and familiarization with ECC cycling at five cadences (30, 45, 60, 75, and 90 rpm); 2) second familiarization with ECC cycling; 3) and 4) ECC cycling exercise consisting of 5 min at the five different cadences at either 40% or 60% PPO. PE was reported, and V̇O 2 and EMG of seven muscles were calculated over the exercise's last minute. RESULTS: PE, V̇O 2 , and global lower limb muscles activation (EMG ALL ) showed an effect of cadence ( P < 0.001) and followed a curvilinear function. Both low and high cadences increased PE and V̇O 2 responses compared with intermediate cadences. Although muscle activation of vastus lateralis follows a U-shaped curve with cadence, it was greater at low cadence for rectus femoris and biceps femoris, greater at high cadence for tibialis anterior and gastrocnemius medialis, and was not altered for soleus. The estimated optimal cadence was greater (all P < 0.01) for V̇O 2 (64.5 ± 7.9 rpm) than PE (61.7 ± 9.4 rpm) and EMG ALL (55.9 ± 9.3 rpm), but power output had no effect on the optimal cadences. CONCLUSIONS: The physiological and perceptual responses to changes in cadence during ECC cycling followed a U-shaped curve with an optimal cadence depending on the parameter considered.

Physiological, Spatiotemporal, Anthropometric, Training, and Performance Characteristics of a 75-Year-Old Multiple World Record Holder Middle-Distance Runner.

PURPOSE: This study assessed the cardiorespiratory capacity, anaerobic speed reserve, and anthropometric and spatiotemporal variables of a 75-year-old world-class middle-distance runner who previously obtained several European and world records in the age categories of 60-70 years, achieved 13 European titles and 15 world champion titles, and also holds several European records for the 75-year-old category. METHODS: Heart rate, oxygen uptake, carbon dioxide production, ventilation, step frequency, contact time, and velocity at maximal oxygen uptake (VO2max) were measured during treadmill running. Maximal sprinting speed was assessed during track sprinting and used to compute anaerobic speed reserve. Body fat percentage was assessed using air displacement plethysmography. RESULTS: Body fat percentage was 8.6%, VO2max was 50.5 mL·kg-1·min-1, maximal ventilation was 141 L·min-1, maximum heart rate was 164 beats·min-1, maximum respiratory exchange ratio was 1.18, and velocity at VO2max was 16.7 km·h-1. The average stride frequency and contact time during the last 30 seconds of the 4-minute run at 10 km·h-1 were 171 steps·min-1 and 241 ms and 187 steps·min-1 and 190 ms in the last 40 seconds at 17 km·h-1, respectively. The anaerobic speed reserve was 11.4 km·h-1, corresponding to an anaerobic speed reserve ratio of 1.68. CONCLUSION: This 75-year-old runner has an exceptionally high VO2max and anaerobic speed reserve ratio. In addition, his resilience to injuries, possibly due to a relatively high volume of easy runs, enabled him to sustain regular training since his 50s and achieve international performance in his age group.

Intermuscular coherence reveals that affective emotional pictures modulate neural control mechanisms during the initiation of arm pointing movements.

Introduction: Several studies in psychology provided compelling evidence that emotions significantly impact motor control. Yet, these evidences mostly rely on behavioral investigations, whereas the underlying neurophysiological processes remain poorly understood. Methods: Using a classical paradigm in motor control, we tested the impact of affective pictures associated with positive, negative or neutral valence on the kinematics and patterns of muscle activations of arm pointing movements performed from a standing position. The hand reaction and movement times were measured and electromyography (EMG) was used to measure the activities from 10 arm, leg and trunk muscles that are involved in the postural maintenance and arm displacement in pointing movements. Intermuscular coherence (IMC) between pairs of muscles was computed to measure changes in patterns of muscle activations related to the emotional stimuli. Results: The hand movement time increased when an emotional picture perceived as unpleasant was presented as compared to when the emotional picture was perceived as pleasant. When an unpleasant emotional picture was presented, beta (ß, 15-35 Hz) and gamma (γ, 35-60 Hz) IMC decreased in the recorded pairs of postural muscles during the initiation of pointing movements. Moreover, a linear relationship between the magnitude of the intermuscular coherence in the pairs of posturo-focal muscles and the hand movement time was found in the unpleasant scenarios. Discussion: These findings reveal that emotional stimuli can significantly affect the content of the motor command sent by the central nervous system to muscles when performing voluntary goal-directed movements.

Corticospinal Excitability Is Lower During Eccentric Than Concentric Cycling in Men.

How corticospinal excitability changes during eccentric locomotor exercise is unknown. In the present study, 13 volunteers performed 30-min strenuous concentric and eccentric cycling bouts at the same power output (60% concentric peak power output). Transcranial magnetic and electrical femoral nerve stimulations were applied at exercise onset (3rd min) and end (25th min). Motor-evoked potentials (MEPs) amplitude was measured for the rectus femoris (RF) and vastus lateralis (VL) muscles with surface electromyography (EMG) and expressed as a percentage of maximal M-wave amplitude (MMAX). EMG amplitude 100 ms prior to MEPs and the silent period duration were calculated. There was no change in any neural parameter during the exercises (all P > 0.24). VL and RF MMAX were unaffected by exercise modality (all P > 0.38). VL MEP amplitude was greater (26 ± 11.4 vs. 15.2 ± 7.7% MMAX; P = 0.008) during concentric than eccentric cycling whereas RF MEP amplitude was not different (24.4 ± 10.8 vs. 17.2 ± 9.8% MMAX; P = 0.051). While VL EMG was higher during concentric than eccentric cycling (P = 0.03), RF EMG showed no significant difference (P = 0.07). Similar silent period durations were found (RF: 120 ± 30 ms; VL: 114 ± 27 ms; all P > 0.61), but the silent period/MEP ratio was higher during eccentric than concentric cycling for both muscles (all P < 0.02). In conclusion, corticospinal excitability to the knee extensors is lower and relative silent period longer during eccentric than concentric cycling, yet both remained unaltered with time.

Concentric versus eccentric cycling at equal power output or effort perception: Neuromuscular alterations and muscle pain.

This study aimed to compare neuromuscular alterations and perceptions of effort and muscle pain induced by concentric and eccentric cycling performed at the same power output or effort perception. Fifteen participants completed three 30-min sessions: one in concentric at 60% peak power output (CON) and two in eccentric, at the same power output (ECCPOWER ) or same perceived effort (ECCEFFORT ). Muscle pain, perception of effort, oxygen uptake as well as rectus femoris and vastus lateralis electromyographic activities were collected when pedaling. The knee extensors maximal voluntary contraction (MVC) torque, the torque evoked by double stimulations at 100 Hz and 10 Hz (Dt100; Dt10), and the voluntary activation level (VAL) were evaluated before and after exercise. Power output was higher in ECCEFFORT than CON (89.1 ± 23.3% peak power). Muscle pain and effort perception were greater in CON than ECCPOWER (p < 0.03) while muscle pain was similar in CON and ECCEFFORT (p > 0.43). MVC torque, Dt100, and VAL dropped in all conditions (p < 0.04). MVC torque (p < 0.001) and the Dt10/ Dt100 ratio declined further in ECCEFFORT (p < 0.001). Eccentric cycling perceived as difficult as concentric cycling caused similar muscle pain but more MVC torque decrease. A given power output induced lower perceptions of pain and effort in eccentric than in concentric yet similar MVC torque decline. While neural impairments were similar in all conditions, eccentric cycling seemed to alter excitation-contraction coupling. Clinicians should thus be cautious when setting eccentric cycling intensity based on effort perception.

Physical Activity and Music to Counteract Mental Fatigue.

Mental fatigue impairs both cognitive and physical performance. Bioactive substances (e.g., caffeine) have been used to counteract mental fatigue but could have side effects. The present study aimed to test two non-bioactive strategies to counteract mental fatigue: physical activity and listening to music. The participants first performed an arm-pointing task, then carried out a 32-min cognitively demanding task to induce mental fatigue (TLDB task), followed by another arm-pointing task at the end of the experiment. Between the end of the cognitively demanding task and the last arm-pointing task, 20 min went during which participants performed either 15 min of physical activity, of listening to music or of discussion (control). The subjective feeling of mental fatigue was assessed before each arm-pointing task and after the cognitively demanding task. For "physical activity" and "listening to music" groups, EEG was recorded at rest after each evaluation of subjective feeling of mental fatigue and during the cognitively demanding task. An increase in alpha power during the cognitively demanding task evidenced the presence of mental fatigue, without recovery during the following 20-min period. In the control condition, the arm-pointing task performance was deteriorated 20-min after the cognitively demanding task, while it remained stable after both physical activity and listening to music. Furthermore, recovery on the subjective feeling of mental fatigue was similar for both groups. The present results suggested that practicing physical activity and listening to music could be efficient strategies to counteract the negative effects of mental fatigue on motor performances.

Effect of Cycling Cadence on Neuromuscular Function: A Systematic Review of Acute and Chronic Alterations.

There is a wide range of cadence available to cyclists to produce power, yet they choose to pedal across a narrow one. While neuromuscular alterations during a pedaling bout at non-preferred cadences were previously reviewed, modifications subsequent to one fatiguing session or training intervention have not been focused on. We performed a systematic literature search of PubMed and Web of Science up to the end of 2020. Thirteen relevant articles were identified, among which eleven focused on fatigability and two on training intervention. Cadences were mainly defined as "low" and "high" compared with a range of freely chosen cadences for given power output. However, the heterogeneity of selected cadences, neuromuscular assessment methodology, and selected population makes the comparison between the studies complicated. Even though cycling at a high cadence and high intensity impaired more neuromuscular function and performance than low-cadence cycling, it remains unclear if cycling cadence plays a role in the onset of fatigue. Research concerning the effect of training at non-preferred cadences on neuromuscular adaptation allows us to encourage the use of various training stimuli but not to say whether a range of cadences favors subsequent neuromuscular performance.

Sub 3-Hour Marathon Runners for Five Consecutive Decades Demonstrate a Reduced Age-Related Decline in Performance.

Estimation of the age-related decline in athletic performance by analyzing age-group world record performances presents an inherent limitation because the records generally belong to different individuals. Longitudinal studies describing the changes in performance with advancing age for the same individuals with a consistent training regimen are more appropriate to determine age-related changes in performance. The aim of this longitudinal study was to examine the age-related decline in running performance of sub 3-h marathoners for five consecutive calendar decades. The best marathon performances for each decade from the 1970s to the 2010s were analyzed for 40 sub 3-h runners (39 males and 1 female). The cohort mean personal best performance was 2 h 23 min ± 9 min at an age of 28.6 ± 4.7 years. The mean difference in age between the first and the last sub 3-h marathon races was 32.9 ± 1.6 years. The time difference in marathon performance between the personal best and the worst performance during the 5th decade was 26 ± 9 min, corresponding to a mean increase of 1 min 4 s per year, i.e., a decrease in running speed of 0.67 ± 0.29% per year. These results suggest that with consistent training and racing regimens, it is possible to limit the age-related decline in marathon performance to less than 7% per decade at least until 60 years of age. Further studies are required to verify if such a low rate of age-related decline in endurance performance could be maintained after 60 years of age.

Locomotor activities as a way of inducing neuroplasticity: insights from conventional approaches and perspectives on eccentric exercises.

Corticospinal excitability, and particularly the balance between cortical inhibitory and excitatory processes (assessed in a muscle using single and paired-pulse transcranial magnetic stimulation), are affected by neurodegenerative pathologies or following a stroke. This review describes how locomotor exercises may counterbalance these neuroplastic alterations, either when performed under its conventional form (e.g., walking or cycling) or when comprising eccentric (i.e., active lengthening) muscle contractions. Non-fatiguing conventional locomotor exercise decreases intracortical inhibition and/or increases intracortical facilitation. These modifications notably seem to be a consequence of neurotrophic factors (e.g., brain-derived neurotrophic factor) resulting from the hemodynamic solicitation. Furthermore, it can be inferred from non-invasive brain and peripheral stimulation studies that repeated activation of neural networks can endogenously shape neuroplasticity. Such mechanisms could also occur following eccentric exercises (lengthening of the muscle), during which motor-related cortical potential (electroencephalography) is of greater magnitude and lasts longer than during concentric exercises (i.e., muscle shortening). As single-joint eccentric exercise decreased short- and long-interval intracortical inhibition and increased intracortical facilitation, locomotor eccentric exercise (e.g., downhill walking or eccentric cycling) may be even more potent by adding hemodynamic-related neuroplastic processes to endogenous processes. Besides, eccentric exercise is especially useful to develop relatively high force levels at low cardiorespiratory and perceived intensities, which can be a training goal alongside the induction of neuroplastic changes. Even though indirect evidence let us think that locomotor eccentric exercise could shape neuroplasticity in ways relevant to neurorehabilitation, its efficacy remains speculative. We provide future research directions on the neuroplastic effects and underlying mechanisms of locomotor exercise.